Publications 2012-2019

Enantioenriched methylene-bridged benzazocanes synthesis by organocatalytic and superacid activations. DOI: 10.1002/anie.201912043. R.Beaud, B. Michelet, Y. Reviriot, A. Martin-Mingot, J. Rodriguez, D. Bonne, S. Thibaudeau, Angew. Chem. Int. Ed. 2019, 58, 2-9.

Structural and computational analysis of 2-halogeno-glycosyl cations in the presence of a superacid: an expansive platform. DOI: 10.1002/anie.201907001. L. Lebedel, A. Arda, A. Martin, J. Désiré, A. Mingot, M. Aufierao, N. Aiguabella Font, R. Gilmour, J. Jiménez-Barbero, Y. Blériot, S. Thibaudeau, Angew. Chem. Int. Ed. 2019, 58, 13758-13762.

Bio-guided fractionation of the ethanolic extract from leaves of Trema orientalis blume (Cannabaceae), a presumed antihypertensive plant from Congo-Brazzaville. DOI: 10.9734/ejmp/2019/v30i430181. L. J. C. Bonazaba Milandou, C. Nkounkou Loumpangou, H. Carreyre, J. Bescond, C. Vandebrouck, E. Ossibi, W. Arnaud, J. -M. Moutsambote, J. -M. Ouamba, S. Thibaudeau, A. A. Abena, Eur. J. Med. Plants 2019, 30, 1-14.

Defining the SN1 side of glycosylation reactions: stereoselectivity of glycopyranosyl cations. DOI: 10.1021/acscentsci.9b00042. T. Hansen, L. Lebedel, W. A. Remmerswaal, S. van der Vorm, D. P. A. Wander, M. Somers, H. S. Overkleeft, D. V. Filippov, J. Désiré, A. Mingot, Y. Blériot, G. A. van der Marel, S. Thibaudeau, J. D. C. Codée, ACS Cent. Sci. 2019, 5, 781-788.

Evidence of Phosphonium-Carbenium Dication Formation in Superacid: Key Precursor of Fluorinated Phosphine Oxides. DOI: 10.1002/anie.201811032.  U. Castelli, J.F. Lohier, I. Drukenmüller, A. Mingot, C. Bachman, C. Alayrac, J. Marrot, K. Stiestorfer, A. Kornath, A.C. Gaumont, S. Thibaudeau, Angew. Chem. Int. Ed. 2019, 58, 1355-1360.

Direct and Selective C-H Carbamoylation of (Hetero)aromatics . with TMSOTf-Activated Carbamoyl Chloride. DOI: 10.1002/ejoc.201801338. A. Uehara, S. Olivero, B. Michelet, A. Martin-Mingot, S. Thibaudeau, E. Duñach, Eur. J. Org. Chem. 2019, 46-49.

Superelectrophilic activation in superacid HF/SbF5: Expanding molecular diversity in nitrogen-containing compounds series by fluorination. DOI:10.1016/j.jfluchem.2018.04.017. B. Michelet, H. Carreyre, F. Lecornué, A. Mingot, S. Thibaudeau, J. Fluor. Chem. 2018, 214, 68-79.

Fluoroenesulfonamides: N-sulfonylurea isosteres showing nanomolar selective cancer-related transmembrane human carbonic anhydrase inhibition. DOI:10.1080/14756366.2018.1461097. B. Métayer, A. Angeli, A. Mingot, K. Jouvin, G. Evano, C. T. Supuran, S. Thibaudeau, J. Enz. Inhib. Med. Chem. 2018, 33, 804-808.

Bioactive natural product and superacid chemistry for lead compound identification: a case study of selective hCA III and L-Type Ca2+ current inhibitors for hypotensive agent discovery. DOI:10.3390/molecules22060915. H. Carreyre, G. Carré, M. Ouédraogo, C. Vandebrouck, J. Bescond, C.T. Supuran, S. Thibaudeau, Molecules 2017, 22, 915/1-915/11.

Cationic polycyclization of ynamides: building up molecular complexity. DOI:10.1039/C7OB00850C. C. Theunissen, B. Métayer, M. Lecomte, N. Henry, H.C. Chan, G. Compain, P. Gérard, C. Bachmann, N. Moktari, J. Marrot, A. Martin-Mingot, S. Thibaudeau, G. Ewano, Org. Biomol. Chem. 2017, 15, 4399-416.

Transformation of the ß-triketone pesticides tembotrione and sulcotrione by reactions with ozone: kinetic study, transformation products, toxicity and biodegradability. DOI:10.1080/01919512.2016.1257933. , A. Tawk, M. Deborde, J. Labanowski, S. Thibaudeau, H. Gallard, Ozone: Science & Engineering 2017, 39, 3-13.

HF-induced Intramolecular C-Arylation and C-Alkylation/Fluorination of 2-Aminoglycopyranoses. DOI: 10.1021/acs.orglett.7b00003. N. Probst, A. Martin, J. Désiré, A. Mingot, J. Marrot, Y. Blériot, S. Thibaudeau, Org. Lett. 2017, 19, 1040-1043.

Superacid-catalyzed trifluoromethylthiolation of aromatic amines. DOI: 10.1002/anie.201609574. L. J. C. Bonazaba Milandou, H. Carreyre, S. Alazet, G. Greco, A. Martin-Mingot, C. Nkounkou Loumpangou, J-M. Ouamba, F. Bouazza, T. Billard, S. Thibaudeau, Angew. Chem. Int. Ed. 2017, 56, 169-172.

A Journey in the Chemistry of Ynamides: From Synthesis to Applications. DOI: 10.1246/cl.160260. G. Evano, N. Blanchard, G. Compain, A. Coste, C. S. Demmer, W. Gati, C. Guissard, J. Heimburger, N. Henry, K. Jouvin, G. Karthikeyan, A. Laouiti, M. Lecomte, A. Martin-Mingot, B. Métayer, B. Michelet, A. Nitelet, C. Theunission, S. Thibaudeau, J. Wang, M. Zarca, C. Zhang, Chem. Lett. 2016, 45, 574-585.

Tandem superelectrophilic activation for the regioselective chlorofluorination of recalcitrant allylic amines. DOI: 10.1016/j.tet.2015.12.013. A. Le Darz, U. Castelli, N. Mokhtari, A. Martin-Mingot, J. Marrot, F. Bouazza, O. Karam, S. Thibaudeau, Tetrahedron 2016, 72, 674-689.

Catching elusive glycosyl cations in a condensed phase with HF/SbF5 superacid. DOI: 10.1038/nchem.2399. A. Martin, A. Arda, J. Désiré, A. Martin-Mingot, N. Probst, P. Sinäy, J. Jimenez-Barbero, S. Thibaudeau, Y. Blériot, Nat. Chem. 2016, 8, 186-191.

Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors. DOI: 10.1039/C5OB01526J. V. Cendret, T. Legigan, A. Mingot, S. Thibaudeau, I. Adachi, M. Forcella, P. Parenti, J. Bertrand, C. Norez, J. Désiré, A. Kato, Y. Blériot, Org. Biomol. Chem. 2015, 13, 10734-10744.

Vasorelaxation induced by dodoneine is mediated by calcium channels blockade and carbonic anhydrase inhibition on vascular smooth muscle cells. DOI: 10.1016/j.jep.2015.03.064. G.Carré, M. Ouedraogo, C. Magaud, H. Carreyre, F. Becq, P. Bois, C. T. Supuran, S. Thibaudeau, C. Vandebrouck, J. Bescond, J. Ethnopharmacol. 2015, 169, 8-17.

Chemo- and Stereoselective Synthesis of Fluorinated Enamides from Ynamides in HF/pyridine: Second-Generation Approach to Potent Ureas Bioisosters. DOI: 10.1021/jo502699y. B. Métayer, G. Compain, K. Jouvin, A. Martin-Mingot, C. Bachmann, J. Marrot, G. Evano, S. Thibaudeau, J. Org. Chem. 2015, 80, 3397-3410.

Fluorinated pyrolidines and piperidines incorporating tertiary benzenesulfonamide moieties are selective carbonic anhydrase II inhibitors. DOI: 10.3109/14756366.2014.963072. A. Le Darz, A. Mingot, F. Bouazza, U. Castelli, O. Karam, M. Tanc, C. T. Supuran, S. Thibaudeau, J. Enz. Inhib. Med. Chem. 2015, 30, 737-745.

Keteniminium ion-initiated cascade cationic polycyclisation. DOI: 10.1021/ja504818. B. Theunissen, B. Métayer, N. Henry, G. Compain, J. Marrot, A. Martin-Mingot, S. Thibaudeau, G. Evano, J. Am. Chem. Soc. 2014, 136, 12528-12531.

The hypotensive agent dodoneine inhibits L-type Ca2+ current with negative inotropic effect on rat heart. DOI: 10.1016/j.ejphar.2014.01.059. G. Carré, H. Carreyre, M. Ouedraogo, F. Becq, P. Bois, S. Thibaudeau, C. Vandebrouck, J. Bescond, Eur. J. Pharmacol. 2014, 728, 119-127.

Superacid synthesized tertiary benzenesulfonamides and benzofuzed sultams act as selective hCA IX inhibitors: toward understanding a new mode of inhibition by tertiary sulfonamides. DOI: 10.1039/C3OB41538D. B. Métayer, A. Mingot, D. Vullo, C. T. Supuran, S. Thibaudeau, Org. Biomol. Chem. 2013, 43, 7540-7549.

New superacid synthesized (fluorinated) tertiary benzenesulfonamides acting as selective hCA IX inhibitors: toward a new mode of carbonic anhydrase inhibition by sulfonamides. DOI: 10.1039/c3cc40858b. B. Métayer, A. Mingot, D. Vullo, C. T. Supuran, S. Thibaudeau, Chem. Commun. 2013, 49, 6015-6017.

Selective Anti-Markovnikov Cyclization and Hydrofluorination Reaction in Superacid HF/SbF5: A Tool in the Design of Nitrogen-Containing (Fluorinated) Polycyclic Systems. DOI: 10.1021/jo400398y. G. Compain, C. Bonneau, A. Martin-Mingot, S. Thibaudeau, J. Org. Chem. 2013, 78, 4463-4472.

Natural product hybrid and its superacid synthesized analogues: Dodoneine and its derivatives show selective inhibition of carbonic anhydrase isoforms I, III, XIII and XIV. DOI: 10.1016/j.bmc.2013.04.041. H. Carreyre, J. -M. Coustard, G. Carré, C. Vandebrouck, J. Bescond, M. Ouedraogo, J. Marrot, D. Vullo, C. T. Supuran, S. Thibaudeau, Bioorg. Med. Chem. 2013, 21, 3790-3794.

Evaluation of the Bronchorelaxant, Genotoxic, and Antigenotoxic Effects of Cassia alata L. DOI: 10.1155/2013/162651. M. Ouédraogo, F. L. Da, A. Fabré, K. Konaté, C. I. Dibala, H. Carreyre, S. Thibaudeau, J.-M. Coustard, C. Vandebrouck, J. Bescond, R. G. Belemtougri, Evidence-Based Complementary and Alternative Medicine 2013, article ID 162651.

Superacid synthesis of halogen containing N-subtituted-4-aminobenzenesulfonamides: New selective tumor-associated carbonic anhydrase inhibitors. DOI: 10.1016/j.bmc.2012.05.037. G. Compain, A. Martin-Mingot, A. Maresca, S. Thibaudeau, C. T. Supuran, Bioorg. Med. Chem. 2013, 21, 1555-1563.

Anti-Markovnikov additions to N-allylic derivatives involving ammonium-carbenium superelectrophiles. DOI: 10.1039/C2CC32246C. G. Compain, A. Martin-Mingot, G. Frapper, C. Bachmann, M-P. Jouannetaud, S. Thibaudeau, Chem. Commun. 2012, 48, 5877-5879.

Stereoselective hydrofluorination of ynamides: a straightforward synthesis of novel α-fluoroenamides. DOI: 10.1039/C2CC31768K. G. Compain, K. Jouvin, A. Martin-Mingot, G. Evano*, J. Marrot, S. Thibaudeau, Chem. Commun. 2012, 48, 5196-5198.

High efficiency of superacid HF/SbF5 for the selective decrystallization–depolymerization of cellulose to glucose. DOI: 10.1039/C2OB07143F. A. Martin-Mingot, K. De Oliveira-Vigier, F. Jérôme, S. Thibaudeau, Org. Biomol. Chem. 2012, 10, 2521-2524.

Dications in superacid HF/SbF5: when superelectrophilic activation makes possible fluorination and/or C–H bond activation. DOI: 10.1016/j.jfluchem.2011.04.022. A. Martin-Mingot, G. Compain, F. Liu, M.-P. Jouannetaud, C. Bachmann, G. Frapper, S. Thibaudeau, J. Fluorine Chem. 2012, 134, 56-62.

Carbonic anhydrases inhibitory effects of new benzenesulfonamides synthesized by using superacid chemistry. DOI: 10.3109/14756366.2011.638921. F. Liu, A. Martin-Mingot, F. Lecornué, M-P. Jouannetaud, A. Maresca, S. Thibaudeau, C. T. Supuran, J. Enz. Inhib. Med. Chem. 2012, 27, 886-891.