Sébastien Thibaudeau

Research interest

Superacid Chemistry – Fluorine Chemistry – Bioactive compounds synthesis –

Research career

  • 2015    Professor position – University of Poitiers – IC2MP
  • 2004    Assistant professor – University of Poitiers – IC2MP
  • 2003-2004  Post-doctoral fellow, Oxford University, UK. Supervisor: Pr. V. Gouverneur (Marie-Curie Fellowship)
  • 1999-2002  PhD in organic chemistry University of Poitiers – UMR 6514 – Supervisor: Pr. J-C. Jacquesy

Teaching

  • University of Poitiers: Fundamental and Applied Science Faculty Master 1/2 Organic Synthesis

 Management/Supervision/Administrative duties

  • Head of the chemistry department UF Chimie University of Poitiers (2020-to date)
  • Member of the management committee of the Insitute of chelmistry UMR 7285 (2012-to date)
  • Co-leader of the organic synthesis team of the Institute of chemistry UMR 7285 (2018-to date)
  • Leader of the Superacid Group of IC2MP (2012-to date)
  • Member of editorial boards: “Journal of Enzyme Inhibition and Medicianl Chemistry” and “Current Enzyme Inhibition”

 Current Funding

  • DAIKIN society – 2019-2021
  • @rtMolecule society – 2020-2022
  • ANR (National research agency) – (ORGASUP/SWEETCAT projects) : 2015-2020
  • EU FEDER 1B : SUPERDIV Project – 2017-2020
  • Javlor® anti-cancer agent Royalties – 2020

Scientific production

  • 56 publications / 2 book chapters
  • 54 invited conferences: 27 in national and international symposiums and 27 in laboratory seminars

Five representative publications

  • Enantioenriched methylene-bridged benzoazocanes synthesis by organocatalytic and superacid activations R. Beaud, B. Michelet, Y. Reviriot, A. Martin-Mingot, J. Rodriguez, D. Bonne and S. Thibaudeau,  Angew. Chem. Int. Ed. 2020, 59, 1279. DOI: 10.1002/anie.201912043.
  • “Evidence of Phosphonium-Carbenium Dication Formation in a Superacid: Precursor to Fluorinated Phosphine Oxides” U. Castelli, J-F. Lohier, I. Drukenmüller, A. Mingot, C. Bachman, C. Alayrac, J. Marrot, K. Stierstorfer, A. Kornath, A-C. Gaumont, S. Thibaudeau,  Angew. Chem. Int. Ed. 2019, 58, 1355. DOI: 10.1002/anie.201811032.
  • “Defining the SN1 side of glycosylation reactions: Stereoselectivity of glycopyranosyl cations”  T. Hansen, L. Lebedel, W. A. Remmerswaal, S. van der Vorm, D. P. A. Wander, M. Somers, H. S. Overkleeft, D. V. Filippov, J. Désiré, A. Mingot, Y. Blériot, G. A. van der Marel, S. Thibaudeau, J. Codee,  ACS Central Sci. 2019, 5, 781-788. DOI: 10.1021/acscentsci.9b00042.
  • “Superacid-catalyzed trifluoromethylthiolation of aromatic amines”  L. J. C. Bonazaba Milandou, H. Carreyre, S. Alazet, G. Greco, A. Martin-Mingot, C. Nkounkou Loumpangou, J-M. Ouamba, F. Bouazza, T. Billard, S. Thibaudeau,  Angew. Chem. Int. Ed. 2017, 56, 169. DOI: 10.1002/anie.201609574.
  • “Catching elusive glycosyl cations in a condensed phase with HF/SbF5”  A. Martin, A. Arda, J. Désiré, A. Martin-Mingot, N. Probst, P. Sinaÿ, J. Jimenez-Barbero, S. Thibaudeau, Y. Blériot,  Nat. Chem. 2016, 8, 186. DOI: 10.1038/nchem.2399.

Publications

  1. N. Bhuma, L. Lebedel, H. Yamashita, Y. Shimizu, Z. Abada, A. Ardá, J. Désiré, B. Michelet, A. Martin-Mingot, A. Abou-Hassan, M. Takumi, J. Marrot, J. Jiménez-Barbero, A. Nagaki, Y. Blériot,S. Thibaudeau Angew. Chem. Int. Ed. 2020, accepted article. DOI: 10.1002/ange.202010175
  2. T. Cantin, Y. Morgenstern, A. Mingot, A. Kornath, S. Thibaudeau, Chem. Commun. 2020, 56, 11110-11113. DOI: 10.1039/d0cc02910f
  3. M. Artault, N. Moktari, T. Cantin, A. Martin-Mingot, S. Thibaudeau, Chem. Commun. 2020, 56, 5905-5908. DOI: 10.1039/d0cc02081h
  4. C. Mahecha-Mahecha, F. Lecornué, S. Akinari, T. Charote, D. Gamba-Sánchez, T. Ohwada, S. Thibaudeau, Org. Lett. 2020, 16, 6267-6271. DOI: 10.1021/acs.orglett.0c02020
  5. B. Michelet, U. Castelli, E. Appert, M. Boucher, K. Vitse, J. Marrot, J. Guillard, A. Martin-Mingot, S. Thibaudeau, Org. Lett. 2020, 13, 4944-4948. DOI : 10.1021/acs.orglett.0c01301
  6.  A. Mamontov, A. Martin-Mingot, B. Métayer, O. Karam, F. Zunino, F. Bouazza, S. Thibaudeau, Chem. Eur. J. 2020, 26, 10411-10416. DOI: 10.1002/chem.202000902
  7. R.Beaud, B. Michelet, Y. Reviriot, A. Martin-Mingot, J. Rodriguez, D. Bonne, S. Thibaudeau, Angew. Chem. Int. Ed. 2019, 58, 2-9. DOI: 10.1002/anie.201912043
  8. L. Lebedel, A. Arda, A. Martin, J. Désiré, A. Mingot, M. Aufierao, N. Aiguabella Font, R. Gilmour, J. Jiménez-Barbero, Y. Blériot, S. Thibaudeau, Angew. Chem. Int. Ed. 2019, 58, 13758-13762. DOI: 10.1002/anie.201907001
  9. L. J. C. Bonazaba Milandou, C. Nkounkou Loumpangou, H. Carreyre, J. Bescond, C. Vandebrouck, E. Ossibi, W. Arnaud, J. -M. Moutsambote, J. -M. Ouamba, S. Thibaudeau, A. A. Abena, Eur. J. Med. Plants 2019, 30, 1-14. DOI: 10.9734/ejmp/2019/v30i430181
  10. T. Hansen, L. Lebedel, W. A. Remmerswaal, S. van der Vorm, D. P. A. Wander, M. Somers, H. S. Overkleeft, D. V. Filippov, J. Désiré, A. Mingot, Y. Blériot, G. A. van der Marel, S. Thibaudeau, J. D. C. Codée, ACS Cent. Sci. 2019, 5, 781-788. DOI: 10.1021/acscentsci.9b00042
  11. U. Castelli, J.F. Lohier, I. Drukenmüller, A. Mingot, C. Bachman, C. Alayrac, J. Marrot, K. Stiestorfer, A. Kornath, A.C. Gaumont, S. Thibaudeau, Angew. Chem. Int. Ed. 2019, 58, 1355-1360. DOI: 10.1002/anie.201811032
  12. A. Uehara, S. Olivero, B. Michelet, A. Martin-Mingot, S. Thibaudeau, E. Duñach, Eur. J. Org. Chem. 2019, 46-49. DOI: 10.1002/ejoc.201801338
  13. B. Michelet, H. Carreyre, F. Lecornué, A. Mingot, S. Thibaudeau, J. Fluor. Chem. 2018, 214, 68-79. DOI:10.1016/j.jfluchem.2018.04.017
  14. B. Métayer, A. Angeli, A. Mingot, K. Jouvin, G. Evano, C. T. Supuran, S. Thibaudeau, J. Enz. Inhib. Med. Chem. 2018, 33, 804-808. DOI:10.1080/14756366.2018.1461097
  15. N. Probst, A. Martin, J. Désiré, A. Mingot, J. Marrot, Y. Blériot, S. Thibaudeau, Org. Lett. 2017, 19, 1040-1043. DOI: 10.1021/acs.orglett.7b00003.
  16. A. Tawk, M. Deborde, J. Labanowski, S. Thibaudeau, H. Gallard, Ozone: Science & Engineering 2017, 39, 3-13. DOI:10.1080/01919512.2016.1257933
  17. L. J. C. Bonazaba Milandou, H. Carreyre, S. Alazet, G. Greco, A. Martin-Mingot, C. Nkounkou Loumpangou, J-M. Ouamba, F. Bouazza, T. Billard, S. Thibaudeau, Angew. Chem. Int. Ed. 2017, 56, 169-172. DOI: 10.1002/anie.201609574
  18. H. Carreyre, G. Carré, M. Ouédraogo, C. Vandebrouck, J. Bescond, C.T. Supuran, S. Thibaudeau, Molecules 2017, 22, 915/1-915/11. DOI:10.3390/molecules22060915
  19. C. Theunissen, B. Métayer, M. Lecomte, N. Henry, H.C. Chan, G. Compain, P. Gérard, C. Bachmann, N. Moktari, J. Marrot, A. Martin-Mingot, S. Thibaudeau, G. Ewano, Org. Biomol. Chem. 2017, 15, 4399-416. DOI:10.1039/C7OB00850C
  20. G. Evano, N. Blanchard, G. Compain, A. Coste, C. S. Demmer, W. Gati, C. Guissard, J. Heimburger, N. Henry, K. Jouvin, G. Karthikeyan, A. Laouiti, M. Lecomte, A. Martin-Mingot, B. Métayer, B. Michelet, A. Nitelet, C. Theunission, S. Thibaudeau, J. Wang, M. Zarca, C. Zhang, Chem. Lett. 2016, 45, 574-585. DOI: 10.1246/cl.160260
  21. A. Le Darz, U. Castelli, N. Mokhtari, A. Martin-Mingot, J. Marrot, F. Bouazza, O. Karam, S. Thibaudeau, Tetrahedron 2016, 72, 674-689. DOI: 10.1016/j.tet.2015.12.013
  22. A. Martin, A. Arda, J. Désiré, A. Martin-Mingot, N. Probst, P. Sinäy, J. Jimenez-Barbero, S. Thibaudeau, Y. Blériot, Nat. Chem. 2016, 8, 186-191. DOI: 10.1038/nchem.2399
  23. V. Cendret, T. Legigan, A. Mingot, S. Thibaudeau, I. Adachi, M. Forcella, P. Parenti, J. Bertrand, C. Norez, J. Désiré, A. Kato, Y. Blériot, Org. Biomol. Chem. 2015, 13, 10734-10744. DOI: 10.1039/C5OB01526J
  24. G.Carré, M. Ouedraogo, C. Magaud, H. Carreyre, F. Becq, P. Bois, C. T. Supuran, S. Thibaudeau, C. Vandebrouck, J. Bescond, J. Ethnopharmacol. 2015, 169, 8-17. DOI: 10.1016/j.jep.2015.03.064
  25. B. Métayer, G. Compain, K. Jouvin, A. Martin-Mingot, C. Bachmann, J. Marrot, G. Evano, S. Thibaudeau, J. Org. Chem. 2015, 80, 3397-3410. DOI: 10.1021/jo502699y
  26. A. Le Darz, A. Mingot, F. Bouazza, U. Castelli, O. Karam, M. Tanc, C. T. Supuran, S. Thibaudeau, J. Enz. Inhib. Med. Chem. 2015, 30, 737-745. DOI: 10.3109/14756366.2014.963072
  27. B. Theunissen, B. Métayer, N. Henry, G. Compain, J. Marrot, A. Martin-Mingot, S. Thibaudeau, G. Evano, J. Am. Chem. Soc. 2014, 136, 12528-12531. DOI: 10.1021/ja504818.
  28. G. Carré, H. Carreyre, M. Ouedraogo, F. Becq, P. Bois, S. Thibaudeau, C. Vandebrouck, J. Bescond, Eur. J. Pharmacol. 2014, 728, 119-127. DOI: 10.1016/j.ejphar.2014.01.059
  29. B. Métayer, A. Mingot, D. Vullo, C. T. Supuran, S. Thibaudeau, Org. Biomol. Chem. 2013, 43, 7540-7549. DOI: 10.1039/C3OB41538D
  30. B. Métayer, A. Mingot, D. Vullo, C. T. Supuran, S. Thibaudeau, Chem. Commun. 2013, 49, 6015-6017. DOI: 10.1039/c3cc40858b.
  31. G. Compain, C. Bonneau, A. Martin-Mingot, S. Thibaudeau, J. Org. Chem. 2013, 78, 4463-4472. DOI: 10.1021/jo400398y
  32. H. Carreyre, J. -M. Coustard, G. Carré, C. Vandebrouck, J. Bescond, M. Ouedraogo, J. Marrot, D. Vullo, C. T. Supuran, S. Thibaudeau, Bioorg. Med. Chem. 2013, 21, 3790-3794. DOI: 10.1016/j.bmc.2013.04.041
  33. M. Ouédraogo, F. L. Da, A. Fabré, K. Konaté, C. I. Dibala, H. Carreyre, S. Thibaudeau, J.-M. Coustard, C. Vandebrouck, J. Bescond, R. G. Belemtougri, Evidence-Based Complementary and Alternative Medicine 2013, article ID 162651. DOI: 10.1155/2013/162651
  34. G. Compain, A. Martin-Mingot, A. Maresca, S. Thibaudeau, C. T. Supuran, Bioorg. Med. Chem. 2013, 21, 1555-1563. DOI: 10.1016/j.bmc.2012.05.037
  35. G. Compain, A. Martin-Mingot, G. Frapper, C. Bachmann, M-P. Jouannetaud, S. Thibaudeau, Chem. Commun. 2012, 48, 5877-5879. DOI: 10.1039/C2CC32246C
  36. G. Compain, K. Jouvin, A. Martin-Mingot, G. Evano*, J. Marrot, S. Thibaudeau, Chem. Commun. 2012, 48, 5196-5198. DOI: 10.1039/C2CC31768K
  37. A. Martin-Mingot, K. De Oliveira-Vigier, F. Jérôme, S. Thibaudeau, Org. Biomol. Chem. 2012, 10, 2521-2524. DOI: 10.1039/C2OB07143F
  38. A. Martin-Mingot, G. Compain, F. Liu, M.-P. Jouannetaud, C. Bachmann, G. Frapper, S. Thibaudeau, J. Fluorine Chem. 2012, 134, 56-62. DOI: 10.1016/j.jfluchem.2011.04.022
  39. F. Liu, A. Martin-Mingot, F. Lecornué, M-P. Jouannetaud, A. Maresca, S. Thibaudeau, C. T. Supuran, J. Enz. Inhib. Med. Chem. 2012, 27, 886-891. DOI: 10.3109/14756366.2011.638921
  40. E. Giovanelli, S. Leroux, L. Moisan, H. Carreyre, P. Thuéry, D-A. Buisson, A. Meddour, J-M. Coustard, S. Thibaudeau, B. Rousseau, M. Nicolas, P. Hellier, E. Doris Org. Lett. 2011, 13, 4116-4119. DOI: 10.1021/ol201637m
  41. F. Liu, A. Martin-Mingot, M-P. Jouannetaud, C. Bachmann, G. Frapper, F. Zunino, S. Thibaudeau Org. Chem. 2011, 76, 1460-1463. DOI: 10.1021/jo102225w
  42. F. Liu, N. Y. Musadji, F. Lecornué, M-P. Jouannetaud, S. Thibaudeau Tetrahedron 2010, 66, 7112-7118. DOI: 10.1016/j.tet.2010.06.095
  43. F. Liu, A. Martin-Mingot, M-P. Jouannetaud, F. Zunino, S. Thibaudeau Org. Lett. 2010, 12, 868-871. DOI: 10.1021/ol9029287
  44. E. Vardelle, A. Martin-Mingot, M-P. Jouannetaud, C. Bachmann, J. Marrot, S. Thibaudeau Org. Chem. 2009, 74, 6025–6034. DOI: 10.1021/jo900881f
  45. L. M. Elphick, S. E. Lee, E. S. Child, A. Prasad, C. Pignocchi, S. Thibaudeau, A. A. Anderson, L. Bonnac, V. Gouverneur, D. J. Mann ChemBioChem 2009, 10, 1519-1526. DOI: 10.1002/cbic.200900052
  46. F. Liu, A. Martin-Mingot, M-P. Jouannetaud, O. Karam, S. Thibaudeau Org. Biomol. Chem. 2009, 7, 4789-4797. DOI: 10.1039/B915077C
  47. E. Vardelle, D. Gamba-Sanchez, A. Martin-Mingot, M-P. Jouannetaud, S. Thibaudeau, J. Marrot Chem. Commun. 2008, 12, 1473-1475. DOI: 10.1039/B815358B
  48. F. Zunino, F. Liu, C. Berrier, A. Martin-Mingot, S. Thibaudeau, M-P. Jouannetaud, J-C. Jacquesy, C. Bachmann Fluorine Chem. 2008, 129, 775-780. (issue spéciale: Fluorine in Biomedicinal Chemistry: invité par Dr K. Kirk). DOI: 10.1016/j.jfluchem.2008.06.020
  49. S. Thibaudeau, A. Martin-Mingot, M.-P. Jouannetaud, O. Karam and F. Zunino Chem. Commun. 2007, 3198-3200. DOI: 10.1039/B703629A
  50. H. Teare, F. Huguet, M. Tredwell, S. Thibaudeau, S. Luthra, V. Gouverneur Arkivoc 2007, Commemorative issue for Professor Alain Krief, 232-244. DOI: 10.3998/ark.5550190.0008.a14
  51. V. Chagnault, S. Thibaudeau, M-P. Jouannetaud, J-C. Jacquesy, A. Cousson, C. Bachmann Fluorine Chem. 2007, 128, 55-59. DOI: 10.1016/j.jfluchem.2006.10.010
  52. S. Debarge, S. Thibaudeau, B. Violeau, A. Martin-Mingot, M-P. Jouannetaud, J-C. Jacquesy, A. Cousson Tetrahedron 2005, 61, 2065-2073. DOI: 10.1016/j.tet.2004.12.045
  53. S. Thibaudeau, R. Fuller, V. Gouverneur Org. Biomol. Chem. 2004, 2, 1110-1112. DOI: 10.1039/B402097A
  54. S. Thibaudeau, V. Gouverneur Org. Lett. 2003, 5, 4891-4893. DOI: 10.1021/ol035991a
  55. S. Thibaudeau, B. Violeau, A. Martin, M-P. Jouannetaud, J-C. Jacquesy Tetrahedron Lett. 2002, 43, 8773-8775.
  56. A. Moine, S. Thibaudeau, A. Martin, M-P. Jouannetaud, J-C. Jacquesy Tetrahedron Lett. 2002, 43, 4119-4122.
  57. S. Thibaudeau, A. Martin-Mingot, M-P. Jouannetaud, J-C. Jacquesy Tetrahedron 2002, 58, 6643-6649.