Publications

  • Publications
Fil d'ariane

Since 2012

60. Benzophenone-Based Phenylogous Peptide Linkage via Friedel–Crafts Acylation.

H. Wu, Y. Otani, Y. Zhou, B. Michelet, S. Thibaudeau, T. Ohwada, L. Chen, Org. Lett. 2025, 44, 12281. DOI: 10.1021/acs.orglett.5c03833.

59. Exploring the behavior of fluorinated sulfonylureas herbicides, trifloxysulfuron and prosulfuron, under oxidative water treatment processes: Chlorination, ozonation, UV photolysis and hydroxyl radical reactions.

R. B. M. Diakabou Oby, H. Carreyre, J. M. Ouamba, S. Thibaudeau, H. Gallard, J. Hazard. Mater. 2025, 499, 140273. DOI: 10.1016/j.jhazmat.2025.140273.

58. Activation of N-containing olefins and alkynes with superacids.

D. Pichon-Barré, H. Carreyre, F. Lecornué, A. Martin-Mingot, B. Michelet, S. Thibaudeau, C. R. Acad. Sci. 2025, 28, 727. DOI: 10.5802/crchim.416. 

57. Regulating the Acidity of HF/Pyridine Media to Control the Chemodivergent Fluoro- and Hydro-heteroalkylation of Olefins.

M. Longuet, F. Naullet, A. Pérochon, A. Martin-Mingot, F. Guégan, B. Michelet, S. Thibaudeau, J. Am. Chem. Soc. 2025, 147, 29079. DOI: 10.1021/jacs.5c07526. 

56. Glycosylium Ions in Superacid Mimic the Transition State of Enzyme Reactions.

M. Armand, A. Nin-Hill, A. Ardá, E. Berrino, J. Désiré, A. Martin-Mingot, B. Michelet, J. Jiménez-Barbero, C. Rovira, Y. Blériot, S. Thibaudeau, J. Am. Chem. Soc. 2024, 146, 32618. DOI: 10.1021/jacs.4c11677. 

55. Superacid-Synthesized Fluorinated Diamines Act as Selective hCA IV Inhibitors.

E. Berrino, B. Michelet, K. Vitse, A. Nocentini, G. Bartolucci, A. Martin-Mingot, P. Gratteri, F. Carta, C. T. Supuran, S. Thibaudeau, J. Med. Chem. 2024, 67, 19460. DOI: 10.1021/acs.jmedchem.4c01795. 

54. Leveraging long-lived arenium ions in superacid for meta-selective methylation.

P. Bourbon, K. Vitse, A. Martin-Mingot, H. Geindre, F. Guégan, B. Michelet, S. Thibaudeau, Nat. Commun. 2024, 15, 7435. DOI: 10.1038/s41467-024-49421-8. 

53. Determination of the Hammett Acidity of HF/Base Reagents.

M. Longuet, K. Vitse, A. Martin-Mingot, B. Michelet, F. Guégan, S. Thibaudeau, J. Am. Chem. Soc. 2024, 146, 12167. DOI: 10.1021/jacs.4c02344. 

52. Exploring Superacid-Promoted Skeletal Reorganization of Aliphatic Nitrogen-Containing Compounds.

M. Artault, T. Cantin, M. Longuet, K. Vitse, C. D. Matatu Mbengo, F. Guégan, B. Michelet, A. Martin-Mingot, S. Thibaudeau, Angew. Chem. Int. Ed. 2024, 63, e202316458. DOI: 10.1002/anie.202316458. 

51. Enantioselective Organocatalysis and Superacid Activation: Challenges and Opportunities.

B. Michelet, A. Martin-Mingot, J. Rodriguez, S. Thibaudeau, D. Bonne, Chem. Eur. J. 2023, e202300440. DOI: 10.1002/chem.202300440. 

50. Exploring F/CF3 substituted oxocarbenium ions for the diastereoselective assembly of highly substituted tetrahydrofuran skeletons.

A. J. Fernandes, B. Michelet, A. Panossian, A. Martin-Mingot, F. R. Leroux, S. Thibaudeau, Chem. Commun. 2023, 59, 4083-4086. DOI: 10.1039/D2CC06521E. 

49. Hidden Heptacyclic Chiral N-Acyl Iminium Ions: A New Entry to Enantioenriched Polycyclic Azepanes and Azocanes by Superacid-Promoted Intramolecular Pictet-Spengler Reaction.

Y. Reviriot, B. Michelet, R. Beaud, A. Martin-Mingot, F. Guégan, S. Thibaudeau, J. Rodriguez, D. Bonne, Chem. A. Eur J. 2022, 28, e202200432. DOI: 10.1002/chem.202200432. 

48. Superacid-Mediated Late-Stage Aromatic Polydeuteration of Pharmaceuticals.

E. Appert, A. Martin-Mingot, O. Karam, F. Zunino, B. Michelet, F. Bouazza, S. Thibaudeau, Chem. A Eur. J. 2022, 28, e202201583. DOI: 10.1002/chem.202201583. 

47. Direct Superacid-Promoted Difluoroethylation of Aromatics.

M. Artault, K. Vitse, A. Martin-Mingot, S. Thibaudeau, Chem. A Eur. J. 2022, 28, e202103926. DOI: 1002/chem.202103926. 

46. Modulating the Efficacy of Carbonic Anhydrase Inhibitors through Fluorine Substitution.

E. Berrino, B. Michelet, A. Martin-Mingot, F. Carta, C. T. Supuran, S. Thibaudeau,  Angew. Chem. Int. Ed. 2021, 60, 23068-23082. DOI: 10.1002/anie.20210321.

45. Formation of Synthetically relevant CF3-Substitute Phenonium Ions in Superacid Media.

A. J. Fernandes; B. Michelet, A. Panossian, A. Martin-Mingot, F. R. Leroux, S. Thibaudeau,  RCS Adv., 2021, 11, 25695-25699. DOI : 10.1039/d1ra04901a. 

44. Complementary Site-Selective Sulfonylation of Aromatic Amines by Superacid Activation.

P. Bourbon, E. Appert, A. Martin-Mingot, B. Michelet, S. Thibaudeau, Org. Lett. 2021, 23, 4115-4120. DOI: 10.1021/acs.orglett.1c00994. 

43. Glycosyl Oxocarbenium Ions: Structure, Conformation, Reactivity, and Interactions.

A. Franconetti, A. Ardá, J. L. Asensio, Y. Blériot, S. Thibaudeau, J. Jiménez-Barbero. Acc. Chem. Res. 2021, 54, 2552-2564. DOI:10.1021/acs.accounts.1c00021. 

42. CF3-substituted carbocations: underexploited intermediates with great potential in modern synthetic chemistry.

A. J. Fernandes, A. Panossian, B. Michelet, A. Martin-Mingot, F. R. Leroux, S. Thibaudeau, Beilstein J. Org. Chem. 2021, 17, 343–37. DOI: 10.3762/bjoc.17.32.

41. Insight into the Ferrier Rearrangement by Combining Flash Chemistry and Superacids.

N. Bhuma, L. Lebedel, H. Yamashita, Y. Shimizu, Z. Abada, A. Ardá, J. Désiré, B. Michelet, A. Martin-Mingot, A. Abou-Hassan, M. Takumi, J. Marrot, J. Jiménez-Barbero, A. Nagaki, Y. Blériot, S. Thibaudeau,  Angew. Chem. Int. Ed. 2021, 60, 2036-2041. DOI: 10.1002/ange.202010175. 

40. Evidence and exploitation of dicationic ammonium–nitrilium superelectrophiles: direct synthesis of unsaturated piperidinones.

T. Cantin, Y. Morgenstern, A. Mingot, A. Kornath, S. Thibaudeau, Chem. Commun. 2020, 56, 11110-11113. DOI: 10.1039/d0cc02910f. 

39. Superelectrophilic Csp3–H bond fluorination of aliphatic amines in superacid: the striking role of ammonium–carbenium dications.

M. Artault, N. Moktari, T. Cantin, A. Martin-Mingot, S. Thibaudeau, Chem. Commun. 2020, 56, 5905-5908. DOI: 10.1039/d0cc02081h. 

38. Sequential Suzuki–Miyaura Coupling/Lewis Acid-Catalyzed Cyclization: An Entry to Functionalized Cycloalkane-Fused Naphthalenes.

C. Mahecha-Mahecha, F. Lecornué, S. Akinari, T. Charote, D. Gamba-Sánchez, T. Ohwada, S. Thibaudeau, Org. Lett. 2020, 16, 6267-6271. DOI: 10.1021/acs.orglett.0c02020. 

37. Access to Optically Pure Benzosultams by Superelectrophilic Activation.

B. Michelet, U. Castelli, E. Appert, M. Boucher, K. Vitse, J. Marrot, J. Guillard, A. Martin-Mingot, S. Thibaudeau, Org. Lett. 2020, 13, 4944-4948. DOI : 10.1021/acs.orglett.0c01301. 

36. Complementary Site‐Selective Halogenation of Nitrogen‐Containing (Hetero)Aromatics with Superacids.

A. Mamontov, A. Martin-Mingot, B. Métayer, O. Karam, F. Zunino, F. Bouazza, S. Thibaudeau, Chem. Eur. J. 2020, 26, 10411-10416. DOI: 10.1002/chem.202000902. 

35. Enantioenriched methylene-bridged benzazocanes synthesis by organocatalytic and superacid activations.

R.Beaud, B. Michelet, Y. Reviriot, A. Martin-Mingot, J. Rodriguez, D. Bonne, S. Thibaudeau, Angew. Chem. Int. Ed. 2019, 58, 2-9. DOI: 10.1002/anie.201912043.

34. Structural and computational analysis of 2-halogeno-glycosyl cations in the presence of a superacid: an expansive platform.

L. Lebedel, A. Arda, A. Martin, J. Désiré, A. Mingot, M. Aufierao, N. Aiguabella Font, R. Gilmour, J. Jiménez-Barbero, Y. Blériot, S. Thibaudeau, Angew. Chem. Int. Ed. 2019, 58, 13758-13762. DOI: 10.1002/anie.201907001. 

33. Bio-guided fractionation of the ethanolic extract from leaves of Trema orientalis blume (Cannabaceae), a presumed antihypertensive plant from Congo-Brazzaville.

L. J. C. Bonazaba Milandou, C. Nkounkou Loumpangou, H. Carreyre, J. Bescond, C. Vandebrouck, E. Ossibi, W. Arnaud, J. -M. Moutsambote, J. -M. Ouamba, S. Thibaudeau, A. A. Abena, Eur. J. Med. Plants 2019, 30, 1-14. DOI: 10.9734/ejmp/2019/v30i430181.

32. Defining the SN1 side of glycosylation reactions: stereoselectivity of glycopyranosyl cations.

T. Hansen, L. Lebedel, W. A. Remmerswaal, S. van der Vorm, D. P. A. Wander, M. Somers, H. S. Overkleeft, D. V. Filippov, J. Désiré, A. Mingot, Y. Blériot, G. A. van der Marel, S. Thibaudeau, J. D. C. Codée, ACS Cent. Sci. 2019, 5, 781-788. DOI: 10.1021/acscentsci.9b00042.

31. Evidence of Phosphonium-Carbenium Dication Formation in Superacid: Key Precursor of Fluorinated Phosphine Oxides.

U. Castelli, J.F. Lohier, I. Drukenmüller, A. Mingot, C. Bachman, C. Alayrac, J. Marrot, K. Stiestorfer, A. Kornath, A.C. Gaumont, S. Thibaudeau, Angew. Chem. Int. Ed. 2019, 58, 1355-1360. DOI: 10.1002/anie.201811032.  

30. Direct and Selective C-H Carbamoylation of (Hetero)aromatics . with TMSOTf-Activated Carbamoyl Chloride.

A. Uehara, S. Olivero, B. Michelet, A. Martin-Mingot, S. Thibaudeau, E. Duñach, Eur. J. Org. Chem. 2019, 46-49. DOI: 10.1002/ejoc.201801338. 

29. Superelectrophilic activation in superacid HF/SbF5: Expanding molecular diversity in nitrogen-containing compounds series by fluorination.

B. Michelet, H. Carreyre, F. Lecornué, A. Mingot, S. Thibaudeau, J. Fluor. Chem. 2018, 214, 68-79. DOI:10.1016/j.jfluchem.2018.04.017. 

28. Fluoroenesulfonamides: N-sulfonylurea isosteres showing nanomolar selective cancer-related transmembrane human carbonic anhydrase inhibition.

B. Métayer, A. Angeli, A. Mingot, K. Jouvin, G. Evano, C. T. Supuran, S. Thibaudeau, J. Enz. Inhib. Med. Chem. 2018, 33, 804-808. DOI:10.1080/14756366.2018.1461097. 

27. Bioactive natural product and superacid chemistry for lead compound identification: a case study of selective hCA III and L-Type Ca2+ current inhibitors for hypotensive agent discovery.

H. Carreyre, G. Carré, M. Ouédraogo, C. Vandebrouck, J. Bescond, C.T. Supuran, S. Thibaudeau, Molecules 2017, 22, 915/1-915/11. DOI:10.3390/molecules22060915. 

26. Cationic polycyclization of ynamides: building up molecular complexity.

C. Theunissen, B. Métayer, M. Lecomte, N. Henry, H.C. Chan, G. Compain, P. Gérard, C. Bachmann, N. Moktari, J. Marrot, A. Martin-Mingot, S. Thibaudeau, G. Evano, Org. Biomol. Chem. 2017, 15, 4399-416. DOI:10.1039/C7OB00850C. 

25. Transformation of the ß-triketone pesticides tembotrione and sulcotrione by reactions with ozone: kinetic study, transformation products, toxicity and biodegradability.

A. Tawk, M. Deborde, J. Labanowski, S. Thibaudeau, H. Gallard, Ozone: Science & Engineering 2017, 39, 3-13. DOI:10.1080/01919512.2016.1257933

24. HF-induced Intramolecular C-Arylation and C-Alkylation/Fluorination of 2-Aminoglycopyranoses.

N. Probst, A. Martin, J. Désiré, A. Mingot, J. Marrot, Y. Blériot, S. Thibaudeau, Org. Lett. 2017, 19, 1040-1043. DOI: 10.1021/acs.orglett.7b00003. 

23. Superacid-catalyzed trifluoromethylthiolation of aromatic amines.

L. J. C. Bonazaba Milandou, H. Carreyre, S. Alazet, G. Greco, A. Martin-Mingot, C. Nkounkou Loumpangou, J-M. Ouamba, F. Bouazza, T. Billard, S. Thibaudeau, Angew. Chem. Int. Ed. 2017, 56, 169-172. DOI: 10.1002/anie.201609574. 

22. Synthesis of fluorinated nitrogen-containing compounds through superelectrophilic activation in superacid HF/SbF5.

S. Thibaudeau, H. Carreyre, A. Mingot. Chapter 13 in Modern Synthesis Processes and Reactivity of Fluorinated Compounds. In Elsevier, 2017, Eds H. Groult, F. R. Leroux and A. Tressaud.

Cover page of the book

21. A Journey in the Chemistry of Ynamides: From Synthesis to Applications.

G. Evano, N. Blanchard, G. Compain, A. Coste, C. S. Demmer, W. Gati, C. Guissard, J. Heimburger, N. Henry, K. Jouvin, G. Karthikeyan, A. Laouiti, M. Lecomte, A. Martin-Mingot, B. Métayer, B. Michelet, A. Nitelet, C. Theunission, S. Thibaudeau, J. Wang, M. Zarca, C. Zhang, Chem. Lett. 2016, 45, 574-585. DOI: 10.1246/cl.160260. 

20. Tandem superelectrophilic activation for the regioselective chlorofluorination of recalcitrant allylic amines.

A. Le Darz, U. Castelli, N. Mokhtari, A. Martin-Mingot, J. Marrot, F. Bouazza, O. Karam, S. Thibaudeau, Tetrahedron 2016, 72, 674-689. DOI: 10.1016/j.tet.2015.12.013. 

19. Catching elusive glycosyl cations in a condensed phase with HF/SbF5 superacid.

A. Martin, A. Arda, J. Désiré, A. Martin-Mingot, N. Probst, P. Sinäy, J. Jimenez-Barbero, S. Thibaudeau, Y. Blériot, Nat. Chem. 2016, 8, 186-191. DOI: 10.1038/nchem.2399. 

18. Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors.

V. Cendret, T. Legigan, A. Mingot, S. Thibaudeau, I. Adachi, M. Forcella, P. Parenti, J. Bertrand, C. Norez, J. Désiré, A. Kato, Y. Blériot, Org. Biomol. Chem. 2015, 13, 10734-10744. DOI: 10.1039/C5OB01526J. 

17. Vasorelaxation induced by dodoneine is mediated by calcium channels blockade and carbonic anhydrase inhibition on vascular smooth muscle cells.

G.Carré, M. Ouedraogo, C. Magaud, H. Carreyre, F. Becq, P. Bois, C. T. Supuran, S. Thibaudeau, C. Vandebrouck, J. Bescond, J. Ethnopharmacol. 2015, 169, 8-17. DOI: 10.1016/j.jep.2015.03.064. 

16. Chemo- and Stereoselective Synthesis of Fluorinated Enamides from Ynamides in HF/pyridine: Second-Generation Approach to Potent Ureas Bioisosters.

B. Métayer, G. Compain, K. Jouvin, A. Martin-Mingot, C. Bachmann, J. Marrot, G. Evano, S. Thibaudeau, J. Org. Chem. 2015, 80, 3397-3410. DOI: 10.1021/jo502699y. 

15. Fluorinated pyrolidines and piperidines incorporating tertiary benzenesulfonamide moieties are selective carbonic anhydrase II inhibitors.

A. Le Darz, A. Mingot, F. Bouazza, U. Castelli, O. Karam, M. Tanc, C. T. Supuran, S. Thibaudeau, J. Enz. Inhib. Med. Chem. 2015, 30, 737-745. DOI: 10.3109/14756366.2014.963072. 

14. Keteniminium ion-initiated cascade cationic polycyclisation.

B. Theunissen, B. Métayer, N. Henry, G. Compain, J. Marrot, A. Martin-Mingot, S. Thibaudeau, G. Evano, J. Am. Chem. Soc. 2014, 136, 12528-12531. DOI: 10.1021/ja504818. 

13. The hypotensive agent dodoneine inhibits L-type Ca2+ current with negative inotropic effect on rat heart.

G. Carré, H. Carreyre, M. Ouedraogo, F. Becq, P. Bois, S. Thibaudeau, C. Vandebrouck, J. Bescond, Eur. J. Pharmacol. 2014, 728, 119-127. DOI: 10.1016/j.ejphar.2014.01.059. 

12. Next-generation secondary/tertiary sulfonamide carbonic anhydrase inhibitors.

S. Thibaudeau, H. Carreyre, A. Mingot, C. T. Supuran. Chapter 1 in Targeting Carbonic Anhydrases. In Future science e-book, 2014, Eds C. Capaso and CT Supuran.

11. Superacid synthesized tertiary benzenesulfonamides and benzofuzed sultams act as selective hCA IX inhibitors: toward understanding a new mode of inhibition by tertiary sulfonamides.

B. Métayer, A. Mingot, D. Vullo, C. T. Supuran, S. Thibaudeau, Org. Biomol. Chem. 2013, 43, 7540-7549. DOI: 10.1039/C3OB41538D. 

10. New superacid synthesized (fluorinated) tertiary benzenesulfonamides acting as selective hCA IX inhibitors: toward a new mode of carbonic anhydrase inhibition by sulfonamides.

B. Métayer, A. Mingot, D. Vullo, C. T. Supuran, S. Thibaudeau, Chem. Commun. 2013, 49, 6015-6017. DOI: 10.1039/c3cc40858b. 

9. Selective Anti-Markovnikov Cyclization and Hydrofluorination Reaction in Superacid HF/SbF5: A Tool in the Design of Nitrogen-Containing (Fluorinated) Polycyclic Systems.

G. Compain, C. Bonneau, A. Martin-Mingot, S. Thibaudeau, J. Org. Chem. 2013, 78, 4463-4472. DOI: 10.1021/jo400398y. 

8. Natural product hybrid and its superacid synthesized analogues: Dodoneine and its derivatives show selective inhibition of carbonic anhydrase isoforms I, III, XIII and XIV.

H. Carreyre, J. -M. Coustard, G. Carré, C. Vandebrouck, J. Bescond, M. Ouedraogo, J. Marrot, D. Vullo, C. T. Supuran, S. Thibaudeau, Bioorg. Med. Chem. 2013, 21, 3790-3794. DOI: 10.1016/j.bmc.2013.04.041.

7. Evaluation of the Bronchorelaxant, Genotoxic, and Antigenotoxic Effects of Cassia alata L.

M. Ouédraogo, F. L. Da, A. Fabré, K. Konaté, C. I. Dibala, H. Carreyre, S. Thibaudeau, J.-M. Coustard, C. Vandebrouck, J. Bescond, R. G. Belemtougri, Evidence-Based Complementary and Alternative Medicine 2013, article ID 162651. DOI: 10.1155/2013/162651. 

6. Superacid synthesis of halogen containing N-subtituted-4-aminobenzenesulfonamides: New selective tumor-associated carbonic anhydrase inhibitors.

G. Compain, A. Martin-Mingot, A. Maresca, S. Thibaudeau, C. T. Supuran, Bioorg. Med. Chem. 2013, 21, 1555-1563. DOI: 10.1016/j.bmc.2012.05.037. 

5. Anti-Markovnikov additions to N-allylic derivatives involving ammonium-carbenium superelectrophiles.

G. Compain, A. Martin-Mingot, G. Frapper, C. Bachmann, M-P. Jouannetaud, S. Thibaudeau, Chem. Commun. 2012, 48, 5877-5879. DOI: 10.1039/C2CC32246C. 

4. Stereoselective hydrofluorination of ynamides: a straightforward synthesis of novel α-fluoroenamides.

G. Compain, K. Jouvin, A. Martin-Mingot, G. Evano*, J. Marrot, S. Thibaudeau, Chem. Commun. 2012, 48, 5196-5198. DOI: 10.1039/C2CC31768K. 

3. High efficiency of superacid HF/SbF5 for the selective decrystallization–depolymerization of cellulose to glucose.

A. Martin-Mingot, K. De Oliveira-Vigier, F. Jérôme, S. Thibaudeau, Org. Biomol. Chem. 2012, 10, 2521-2524. DOI: 10.1039/C2OB07143F.

2. Dications in superacid HF/SbF5: when superelectrophilic activation makes possible fluorination and/or C–H bond activation.

A. Martin-Mingot, G. Compain, F. Liu, M.-P. Jouannetaud, C. Bachmann, G. Frapper, S. Thibaudeau, J. Fluorine Chem. 2012, 134, 56-62. DOI: 10.1016/j.jfluchem.2011.04.022. 

1. Carbonic anhydrases inhibitory effects of new benzenesulfonamides synthesized by using superacid chemistry.

F. Liu, A. Martin-Mingot, F. Lecornué, M-P. Jouannetaud, A. Maresca, S. Thibaudeau, C. T. Supuran, J. Enz. Inhib. Med. Chem. 2012, 27, 886-891. DOI: 10.3109/14756366.2011.638921. 

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